Dr. Herman Weiss

The Gut-Brain Axis: Why Your Gut Controls Your Mood.

The neuroscience of the PCOS gut-brain connection. Serotonin, tryptophan, the kynurenine pathway, and what probiotic RCTs show about depression and anxiety in women with PCOS.

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Dr. Herman Weiss
Mar 30, 2026
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THE GUT FILES · PART 4 OF 6 · @hweissmd · PAID SUBSCRIBER ISSUE

Your Gut, Your Hormones, Your PCOS — The Microbiome Series

The Gut-Brain Axis: Why Your Gut Controls Your Mood.

The neuroscience of the PCOS gut-brain connection. Serotonin, tryptophan, the kynurenine pathway, and what probiotic RCTs show about depression and anxiety in women with PCOS.

Herman Weiss, MD, MBA, FACOG · Board-Certified OB/GYN · CEO, ProvationLife · Founder, KetoPulse

THE QUESTION NOBODY ASKS THEIR GYN

If you have PCOS, you have almost certainly experienced the following: a clinician attributes your anxiety or depression to the stress of living with a chronic condition. The implication is that your emotional state is a psychological response to your diagnosis — not a biological consequence of the same underlying physiology that is driving your irregular cycles and elevated testosterone.

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