Inositol in PCOS: A Cellular and Molecular Deep Dive
Inositol — specifically myo-inositol (MI) and D-chiro-inositol (DCI) — is not a simple supplement. It is a biologically active signaling molecule.
EXECUTIVE SUMMARY
Inositol — specifically myo-inositol (MI) and D-chiro-inositol (DCI) — is not a simple supplement. It is a biologically active signaling molecule operating at the intersection of insulin transduction, gonadotropin signaling, and ovarian steroidogenesis. In PCOS, a precisely described disruption in the MI/DCI tissue ratio — the “ovarian paradox” — drives hyperandrogenism, anovulation, and insulin resistance simultaneously. Understanding the cellular mechanisms explains both why inositol works and why getting the ratio wrong can make things worse.
